SCHEMBL19085988

SCHEMBL19085988

CC[C@@H](NC(=O)c1cc2cn[nH]c2cc1OC)C(=O)N1CCc2sc(C(=O)Nc3ccccc3)cc2C1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 5/20 0.40
HCRTR1 O43613 3/20 0.38
FPR2 P25090 2/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
POLB P06746 1/20 0.37
KDM4E B2RXH2 3/20 0.37
ALDH1A1 P00352 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
HTT P42858 1/20 0.37
PRMT5 O14744 3/20 0.37
WDR77 Q9BQA1 3/20 0.37
TSHR P16473 1/20 0.37
HSD17B10 Q99714 1/20 0.37
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
THRB P10828 1/20 0.37
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19085998 0.90 PRMT5 (0.39) NPC1RAB9ASMN1; SMN2HPGDPRMT5
SCHEMBL19085981 0.87 TRPV1 (0.41) HCRTR2NPC1RAB9APRMT5WDR77
SCHEMBL19085999 0.87 TRPV1 (0.41) HCRTR2NPC1RAB9APRMT5WDR77
SCHEMBL19086210 0.86 KDM1A (0.40) NPC1RAB9APOLBKDM4EALDH1A1
SCHEMBL19085975 0.84 PRMT5 (0.37) HCRTR2HCRTR1PRMT5WDR77
SCHEMBL19085990 0.83 BRAF (0.40) HCRTR2HCRTR1PRMT5WDR77SMO
SCHEMBL19085977 0.80 NPC1 (0.45) NPC1RAB9AKDM4EMAPTPRMT5
SCHEMBL19086256 0.80 NPC1 (0.41) NPC1RAB9APRMT5WDR77MAOA
SCHEMBL19085989 0.80 MAOB (0.41) NPC1RAB9AMAOAMAOB
SCHEMBL19085978 0.80 ROCK2 (0.46) NPC1RAB9APRMT5WDR77MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017114275-A1 COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME 成都先导药物开发有限公司 2017-07-06 WO disclosed