Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15574024 | 0.87 | ALDH1A1 (0.46) | MMP8NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL15573062 | 0.84 | SIGMAR1 (0.40) | DPP4 | |
| SCHEMBL6132997 | 0.83 | SIGMAR1 (0.44) | GRM2 | |
| SCHEMBL3234426 | 0.83 | ALDH1A1 (0.43) | DPP4MAOBFKBP1ANPC1HTT | |
| SCHEMBL7244148 | 0.83 | SIGMAR1 (0.44) | GRM2 | |
| SCHEMBL945183 | 0.81 | SIGMAR1 (0.47) | — | |
| SCHEMBL1880066 | 0.81 | SIGMAR1 (0.47) | — | |
| SCHEMBL4690079 | 0.81 | LTA4H (0.41) | MAOB | |
| SCHEMBL945182 | 0.81 | SIGMAR1 (0.47) | — | |
| Hydrochloric Acid SCHEMBL1730624 | 0.80 | SIGMAR1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888241-B1 | 2,4,5,6-Substituted 3,6-dihydropyrimidine derivatives as hepatitis B virus (HBV) polymerase inhibitors for the treatment of e.g. chronic hepatitis | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-07-12 | — | — | EP | disclosed |