Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086147 | 0.92 | ROCK2 (0.37) | ROCK2ROCK1HCRTR2METTL3PRMT5 | |
| SCHEMBL19086163 | 0.85 | METTL3 (0.37) | ROCK2ROCK1METTL3PRMT5WDR77 | |
| SCHEMBL19085986 | 0.83 | PRMT5 (0.39) | ROCK2ROCK1HCRTR2METTL3PRMT5 | |
| SCHEMBL19086160 | 0.81 | HDAC6 (0.38) | ROCK2ROCK1METTL3PRMT5WDR77 | |
| SCHEMBL19086037 | 0.81 | RPS6KB1 (0.42) | ROCK2ROCK1METTL3PRMT5WDR77 | |
| SCHEMBL19086153 | 0.80 | KMT2A (0.49) | ROCK2ROCK1HCRTR2PRMT5WDR77 | |
| SCHEMBL19086182 | 0.79 | SMO (0.40) | ROCK2METTL3PRMT5WDR77 | |
| SCHEMBL19085999 | 0.79 | TRPV1 (0.41) | ROCK2ROCK1HCRTR2PRMT5WDR77 | |
| SCHEMBL19085981 | 0.79 | TRPV1 (0.41) | ROCK2ROCK1HCRTR2PRMT5WDR77 | |
| SCHEMBL19086162 | 0.79 | KMT2A (0.40) | ROCK2ROCK1HCRTR2METTL3PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |