SCHEMBL19086153

SCHEMBL19086153

CNC(=O)c1cc2c(s1)CCN(C(=O)[C@@H](Cc1ccccc1)NC(=O)c1ccc3[nH]ncc3c1)C2

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.49
HCRTR2 O43614 5/20 0.47
HCRTR1 O43613 3/20 0.45
ROCK2 O75116 4/20 0.44
ROCK1 Q13464 2/20 0.44
CYP3A4 P08684 4/20 0.42
CALCRL Q16602 2/20 0.39
PRMT5 O14744 4/20 0.39
WDR77 Q9BQA1 4/20 0.39
DDR1 Q08345 1/20 0.39
GRIN2B Q13224 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19086162 0.93 KMT2A (0.40) KMT2AHCRTR2HCRTR1ROCK2ROCK1
SCHEMBL19086154 0.88 F10 (0.43) ROCK2ROCK1CYP3A4PRMT5WDR77
SCHEMBL19085984 0.87 ROCK2 (0.42) KMT2AHCRTR2ROCK2ROCK1PRMT5
SCHEMBL19086161 0.86 HDAC6 (0.41) ROCK2ROCK1CYP3A4PRMT5WDR77
SCHEMBL19085983 0.86 ROCK2 (0.43) KMT2AHCRTR2HCRTR1ROCK2ROCK1
SCHEMBL19085999 0.86 TRPV1 (0.41) KMT2AHCRTR2ROCK2ROCK1PRMT5
SCHEMBL19085981 0.86 TRPV1 (0.41) KMT2AHCRTR2ROCK2ROCK1PRMT5
SCHEMBL19086025 0.85 ENPP2 (0.43) ROCK2CYP3A4PRMT5WDR77
SCHEMBL19086156 0.84 HDAC6 (0.41) ROCK2ROCK1CYP3A4PRMT5WDR77
SCHEMBL19086148 0.83 HDAC6 (0.40) ROCK2ROCK1CYP3A4PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017114275-A1 COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME 成都先导药物开发有限公司 2017-07-06 WO disclosed