SCHEMBL19086166 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	HDAC6	Q9UBN7	3/20	0.36

▸	ROCK2	O75116	6/20	0.35

▸	LRRK2	Q5S007	2/20	0.34

▸	PRMT5	O14744	6/20	0.34

▸	WDR77	Q9BQA1	6/20	0.34

▸	NTRK1	P04629	1/20	0.34

▸	METTL3	Q86U44	1/20	0.34

▸	RPS6KA3	P51812	1/20	0.34

▸	RPS6KA2	Q15349	1/20	0.34

▸	ROCK1	Q13464	4/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086170	0.88	METTL3 (0.36)	HDAC6ROCK2PRMT5WDR77METTL3
SCHEMBL19086167	0.87	METTL3 (0.37)	HDAC6ROCK2LRRK2METTL3
SCHEMBL19085999	0.87	TRPV1 (0.41)	ROCK2PRMT5WDR77ROCK1
SCHEMBL19085981	0.87	TRPV1 (0.41)	ROCK2PRMT5WDR77ROCK1
SCHEMBL19086160	0.86	HDAC6 (0.38)	HDAC6ROCK2PRMT5WDR77METTL3
SCHEMBL19085977	0.86	NPC1 (0.45)	HDAC6ROCK2PRMT5WDR77ROCK1
SCHEMBL19086252	0.85	ROCK2 (0.37)	ROCK2PRMT5WDR77ROCK1
SCHEMBL19086169	0.85	METTL3 (0.37)	HDAC6ROCK2LRRK2METTL3ROCK1
SCHEMBL19086147	0.85	ROCK2 (0.37)	HDAC6ROCK2PRMT5WDR77METTL3
SCHEMBL19085987	0.84	KDM1A (0.41)	ROCK2PRMT5WDR77ROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed