SCHEMBL19086170 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	METTL3	Q86U44	1/20	0.36

▸	PRMT5	O14744	11/20	0.35

▸	WDR77	Q9BQA1	11/20	0.35

▸	ROCK2	O75116	2/20	0.35

▸	HDAC6	Q9UBN7	2/20	0.34

▸	ABL1	P00519	2/20	0.34

▸	ACACB	O00763	1/20	0.33

▸	BTK	Q06187	1/20	0.33

▸	BCR	P11274	1/20	0.33

▸	ROCK1	Q13464	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086166	0.88	HDAC6 (0.36)	METTL3PRMT5WDR77ROCK2HDAC6
SCHEMBL19086169	0.87	METTL3 (0.37)	METTL3ROCK2HDAC6ABL1BTK
SCHEMBL19086167	0.86	METTL3 (0.37)	METTL3ROCK2HDAC6BTK
SCHEMBL19085999	0.86	TRPV1 (0.41)	PRMT5WDR77ROCK2ROCK1
SCHEMBL19085981	0.86	TRPV1 (0.41)	PRMT5WDR77ROCK2ROCK1
SCHEMBL19085993	0.85	BTK (0.38)	METTL3PRMT5WDR77ROCK2BTK
SCHEMBL19086004	0.85	PRMT5 (0.39)	METTL3PRMT5WDR77ROCK2HDAC6
SCHEMBL19086160	0.85	HDAC6 (0.38)	METTL3PRMT5WDR77ROCK2HDAC6
SCHEMBL19086255	0.85	MEN1 (0.39)	ROCK2ROCK1
SCHEMBL19085977	0.84	NPC1 (0.45)	PRMT5WDR77ROCK2HDAC6ROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed