SCHEMBL19086176

SCHEMBL19086176

NCC(=O)N1CCc2sc(C(=O)Nc3ccccc3)cc2C1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 5/20 0.51
PRMT5 O14744 4/20 0.49
WDR77 Q9BQA1 4/20 0.49
HDAC6 Q9UBN7 7/20 0.48
MAPT P10636 5/20 0.45
NPC1 O15118 4/20 0.45
RAB9A P51151 3/20 0.45
ALDH1A1 P00352 3/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
NFKB1 P19838 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45
LMNA P02545 4/20 0.44
KDM4E B2RXH2 1/20 0.43
TP53 P04637 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
F2 P00734 1/20 0.42
TPSAB1 Q15661 1/20 0.42
TPSD1 Q9BZJ3 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19086175 0.83 HDAC6 (0.47) KDM1APRMT5WDR77HDAC6MAPT
SCHEMBL19086350 0.81 MAPT (0.48) PRMT5WDR77HDAC6MAPTNPC1
SCHEMBL19086191 0.81 TMEM97 (0.48) PRMT5WDR77HDAC6MAPTALDH1A1
SCHEMBL28523454 0.77 HDAC6 (0.53) KDM1APRMT5WDR77HDAC6MAPT
SCHEMBL28523456 0.77 HDAC6 (0.53) KDM1APRMT5WDR77HDAC6MAPT
SCHEMBL19087013 0.76 KDM1A (0.46) KDM1APRMT5WDR77HDAC6ALDH1A1
SCHEMBL13822812 0.76 KDM1A (0.60) KDM1APRMT5WDR77HDAC6MAPT
SCHEMBL19086200 0.75 HDAC6 (0.48) KDM1APRMT5WDR77HDAC6MAPT
SCHEMBL19086240 0.75 EGFR (0.43) KDM1APRMT5WDR77HDAC6ALDH1A1
SCHEMBL19086347 0.74 KDM1A (0.46) KDM1APRMT5WDR77HDAC6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017114275-A1 COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME 成都先导药物开发有限公司 2017-07-06 WO disclosed