SCHEMBL19086347 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	KDM1A	O60341	5/20	0.46

▸	HDAC6	Q9UBN7	4/20	0.44

▸	JAK2	O60674	1/20	0.43

▸	JAK1	P23458	1/20	0.43

▸	PRMT5	O14744	8/20	0.40

▸	WDR77	Q9BQA1	8/20	0.40

▸	AURKA	O14965	1/20	0.40

▸	MAPK1	P28482	1/20	0.39

▸	ALDH1A1	P00352	1/20	0.39

▸	L3MBTL1	Q9Y468	1/20	0.39

▸	HTT	P42858	1/20	0.39

▸	SMN1; SMN2	Q16637	1/20	0.39

▸	NAMPT	P43490	1/20	0.38

▸	FLT3	P36888	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086001	0.84	JAK2 (0.40)	KDM1AJAK2JAK1PRMT5WDR77
SCHEMBL19086240	0.77	EGFR (0.43)	KDM1AHDAC6JAK2PRMT5WDR77
SCHEMBL19086230	0.76	MAOB (0.44)	—
SCHEMBL19086183	0.76	KDM1A (0.40)	KDM1AHDAC6L3MBTL1
SCHEMBL19087013	0.75	KDM1A (0.46)	KDM1AHDAC6PRMT5WDR77ALDH1A1
SCHEMBL19086176	0.74	KDM1A (0.51)	KDM1AHDAC6PRMT5WDR77ALDH1A1
SCHEMBL19086026	0.74	METTL3 (0.44)	KDM1AHDAC6PRMT5WDR77ALDH1A1
SCHEMBL19086210	0.74	KDM1A (0.40)	KDM1AHDAC6PRMT5WDR77ALDH1A1
SCHEMBL19086202	0.73	KDM1A (0.48)	KDM1AHDAC6PRMT5WDR77ALDH1A1
SCHEMBL19086208	0.71	KDM1A (0.44)	KDM1AHDAC6PRMT5WDR77ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed