Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086320 | 0.82 | KDM4E (0.56) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL19086231 | 0.82 | ALDH1A1 (0.56) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL19086022 | 0.77 | RAB9A (0.56) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL19086175 | 0.76 | HDAC6 (0.47) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL19086191 | 0.76 | TMEM97 (0.48) | MAPTALDH1A1KMT2AMEN1HDAC6 | |
| SCHEMBL19087009 | 0.75 | ALDH1A1 (0.49) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28523456 | 0.74 | HDAC6 (0.53) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28523454 | 0.74 | HDAC6 (0.53) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL19086177 | 0.73 | PNMT (0.58) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL19086996 | 0.73 | NPC1 (0.45) | ALDH1A1RAB9ANPC1SMN1; SMN2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |