SCHEMBL19086184

SCHEMBL19086184

CC[C@@H](NC(=O)c1ccc(N)c(C=N)c1)C(=O)N1CCc2sc(C(=O)NC3CCN(C)CC3)cc2C1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 3/20 0.37
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
PRNP P04156 1/20 0.35
DCLK1 O15075 1/20 0.35
PDPK1 O15530 1/20 0.35
PRKD3 O94806 1/20 0.35
MAP4K4 O95819 1/20 0.35
CHEK2 O96017 1/20 0.35
PIM1 P11309 1/20 0.35
MAPK1 P28482 1/20 0.35
AXL P30530 1/20 0.35
FLT4 P35916 1/20 0.35
FLT3 P36888 1/20 0.35
MAPK9 P45984 1/20 0.35
CSNK1D P48730 1/20 0.35
IRAK1 P51617 1/20 0.35
RPS6KA3 P51812 1/20 0.35
PRKX P51817 1/20 0.35
NEK4 P51957 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19086241 0.94 HDAC6 (0.36) HDAC6NPC1RAB9APRNPPRMT5
SCHEMBL19086219 0.92 HDAC6 (0.36) HDAC6NPC1RAB9APRNPPRMT5
SCHEMBL19086206 0.91 HDAC6 (0.38) HDAC6PRMT5WDR77KDM1AHCRTR2
SCHEMBL19086216 0.90 HDAC6 (0.35) HDAC6PRMT5WDR77KDM1AHCRTR2
SCHEMBL19086017 0.90 HDAC6 (0.36) HDAC6PRMT5WDR77KDM1A
SCHEMBL19086335 0.88 HDAC6 (0.39) HDAC6PRMT5WDR77HCRTR2
SCHEMBL19086201 0.85 PRMT5 (0.40) HDAC6PRMT5WDR77GAA
SCHEMBL19086194 0.84 PRMT5 (0.43) PRMT5WDR77HCRTR2
SCHEMBL19086009 0.84 KMT2A (0.42) PRMT5WDR77SMN1; SMN2HCRTR2
SCHEMBL19086006 0.83 KDM4E (0.38) HDAC6PRMT5WDR77SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017114275-A1 COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME 成都先导药物开发有限公司 2017-07-06 WO disclosed