Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 11/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086017 | 0.94 | HDAC6 (0.36) | HDAC6PRMT5WDR77KDM1A | |
| SCHEMBL19086184 | 0.91 | HDAC6 (0.37) | HDAC6PRMT5WDR77KDM1AHCRTR2 | |
| SCHEMBL19086241 | 0.90 | HDAC6 (0.36) | HDAC6PRMT5WDR77KDM1A | |
| SCHEMBL19086216 | 0.88 | HDAC6 (0.35) | HDAC6PRMT5WDR77KDM1AHCRTR2 | |
| SCHEMBL19086219 | 0.88 | HDAC6 (0.36) | HDAC6PRMT5WDR77KDM1A | |
| SCHEMBL19086335 | 0.88 | HDAC6 (0.39) | HDAC6PRMT5WDR77HCRTR2KMT2A | |
| SCHEMBL19086201 | 0.85 | PRMT5 (0.40) | HDAC6PRMT5WDR77 | |
| SCHEMBL19086194 | 0.84 | PRMT5 (0.43) | PRMT5WDR77HCRTR2KMT2A | |
| SCHEMBL19086009 | 0.84 | KMT2A (0.42) | PRMT5WDR77HCRTR2KMT2A | |
| SCHEMBL19086006 | 0.83 | KDM4E (0.38) | HDAC6PRMT5WDR77KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |