SCHEMBL19086234 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	EPHX2	P34913	5/20	0.43

▸	ROCK2	O75116	5/20	0.39

▸	MAOB	P27338	1/20	0.38

▸	METTL3	Q86U44	1/20	0.38

▸	PRMT5	O14744	3/20	0.37

▸	WDR77	Q9BQA1	3/20	0.37

▸	MMP13	P45452	1/20	0.36

▸	HCRTR2	O43614	2/20	0.35

▸	ROCK1	Q13464	3/20	0.35

▸	SLC8A1	P32418	1/20	0.35

▸	NAMPT	P43490	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086349	0.91	MAOB (0.40)	ROCK2MAOBMETTL3PRMT5WDR77
SCHEMBL19086994	0.91	MAOB (0.39)	ROCK2MAOBMETTL3PRMT5WDR77
SCHEMBL19086205	0.91	MAOB (0.39)	ROCK2MAOBMETTL3PRMT5WDR77
SCHEMBL19086985	0.90	PRMT5 (0.41)	ROCK2MAOBMETTL3PRMT5WDR77
SCHEMBL19085996	0.89	ROCK2 (0.53)	ROCK2PRMT5WDR77ROCK1NAMPT
SCHEMBL19085995	0.88	METTL3 (0.41)	ROCK2MAOBMETTL3PRMT5WDR77
SCHEMBL19085984	0.88	ROCK2 (0.42)	ROCK2MAOBMETTL3PRMT5WDR77
SCHEMBL19085991	0.87	MAOB (0.42)	ROCK2MAOBMETTL3PRMT5WDR77
SCHEMBL19085994	0.86	ROCK2 (0.41)	ROCK2MAOBMETTL3PRMT5WDR77
SCHEMBL19086023	0.85	NAMPT (0.38)	ROCK2MAOBMETTL3PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed