Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086254 | 0.90 | PRMT5 (0.40) | PRMT5WDR77DDR2ENPP2MAOB | |
| SCHEMBL19086256 | 0.89 | NPC1 (0.41) | PRMT5WDR77MAOBMEN1NPC1 | |
| SCHEMBL19085977 | 0.88 | NPC1 (0.45) | PRMT5WDR77MAOBHDAC6MEN1 | |
| SCHEMBL19085999 | 0.88 | TRPV1 (0.41) | PRMT5WDR77TRPV1MAOBNPC1 | |
| SCHEMBL19085981 | 0.88 | TRPV1 (0.41) | PRMT5WDR77TRPV1MAOBNPC1 | |
| SCHEMBL19085978 | 0.86 | ROCK2 (0.46) | PRMT5WDR77TRPV1MAOBNPC1 | |
| SCHEMBL19086178 | 0.85 | NPC1 (0.38) | TRPV1MAOBMEN1NPC1RAB9A | |
| SCHEMBL19086255 | 0.85 | MEN1 (0.39) | TRPV1MAOBMEN1NPC1RAB9A | |
| SCHEMBL19086167 | 0.85 | METTL3 (0.37) | TRPV1MAOBHDAC6MEN1NPC1 | |
| SCHEMBL19086169 | 0.84 | METTL3 (0.37) | DDR2ABL1TRPV1MAOBBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |