Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 4/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19085976 | 0.92 | DDR2 (0.46) | PRMT5WDR77MAOBDDR2NAMPT | |
| SCHEMBL19086023 | 0.91 | NAMPT (0.38) | PRMT5WDR77MAOBNAMPTMETTL3 | |
| SCHEMBL19086257 | 0.90 | PRMT5 (0.38) | PRMT5WDR77MAOBDDR2ENPP2 | |
| SCHEMBL19086985 | 0.89 | PRMT5 (0.41) | PRMT5WDR77MAOBNAMPTMETTL3 | |
| SCHEMBL19085984 | 0.88 | ROCK2 (0.42) | PRMT5WDR77MAOBMETTL3 | |
| SCHEMBL19085991 | 0.87 | MAOB (0.42) | PRMT5WDR77MAOBNAMPTMETTL3 | |
| SCHEMBL19085994 | 0.86 | ROCK2 (0.41) | PRMT5WDR77MAOBNAMPTMETTL3 | |
| SCHEMBL19086042 | 0.86 | PRMT5 (0.38) | PRMT5WDR77MAOBENPP2METTL3 | |
| SCHEMBL19086994 | 0.85 | MAOB (0.39) | PRMT5WDR77MAOBNAMPTMETTL3 | |
| SCHEMBL19086205 | 0.85 | MAOB (0.39) | PRMT5WDR77MAOBNAMPTMETTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |