Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.50 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.50 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31359444 | 0.86 | PLA2G1B (0.52) | PTGDR2L3MBTL1SMN1; SMN2GLATDP1 | |
| SCHEMBL19086323 | 0.86 | PLA2G1B (0.52) | PTGDR2L3MBTL1SMN1; SMN2GLATDP1 | |
| SCHEMBL1947848 | 0.84 | L3MBTL1 (0.72) | PTGDR2L3MBTL1SMN1; SMN2POLBGLA | |
| SCHEMBL5379717 | 0.84 | L3MBTL1 (0.63) | PTGDR2L3MBTL1SMN1; SMN2POLBGLA | |
| SCHEMBL7806644 | 0.81 | PTGDR2 (0.65) | PTGDR2L3MBTL1SMN1; SMN2POLBGLA | |
| SCHEMBL29997360 | 0.80 | PDCD1 (0.50) | L3MBTL1SMN1; SMN2GLATDP1LMNA | |
| SCHEMBL2059383 | 0.80 | POLB (0.58) | PTGDR2L3MBTL1SMN1; SMN2POLBGLA | |
| SCHEMBL7654284 | 0.79 | L3MBTL1 (0.55) | PTGDR2L3MBTL1SMN1; SMN2POLBGLA | |
| SCHEMBL7047572 | 0.78 | PDCD1 (0.49) | L3MBTL1SMN1; SMN2TDP1LMNAMAPK1 | |
| SCHEMBL6746949 | 0.78 | L3MBTL1 (0.56) | PTGDR2L3MBTL1SMN1; SMN2POLBGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190016681-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2019-01-17 | — | — | US | disclosed |
| US-20190016681-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2019-01-17 | — | — | US | disclosed |
| EP-3400213-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | Rijksuniversiteit Groningen (NL) | 2018-11-14 | — | — | EP | disclosed |
| WO-2017118762-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2017-07-13 | — | — | WO | disclosed |
| WO-2017118762-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2017-07-13 | — | — | WO | disclosed |
| EP-3190103-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | Rijksuniversiteit Groningen (NL) | 2017-07-12 | — | — | EP | disclosed |
| EP-3190103-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | Rijksuniversiteit Groningen (NL) | 2017-07-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190016681-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | PDCD1, CD274, PDCD1LG2 | PTGDR2 2823/4885L3MBTL1 1347/4885SMN1; SMN2 4474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.