Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | BACE1 | P56817 | 5/20 | 0.57 |
| ▸ | BCHE | P06276 | 4/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.56 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.55 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687045 | 0.85 | ACHE (0.59) | ACHEKDM4EGAAHRH3BACE1 | |
| SCHEMBL3328074 | 0.84 | ACHE (0.60) | ACHEKDM4EGAAHRH3BACE1 | |
| SCHEMBL4218644 | 0.84 | ACHE (0.58) | ACHEKDM4EGAAHRH3BACE1 | |
| SCHEMBL19492792 | 0.83 | ACHE (0.58) | ACHEKDM4EGAAHRH3BACE1 | |
| SCHEMBL4227761 | 0.82 | ACHE (0.57) | ACHEKDM4EGAAHRH3BACE1 | |
| SCHEMBL3359734 | 0.81 | DRD2 (0.71) | ACHEKDM4EGAAHRH3BACE1 | |
| SCHEMBL16990442 | 0.80 | TDO2 (0.77) | ACHE | |
| SCHEMBL3997031 | 0.80 | ACHE (0.68) | ACHEKDM4EGAABACE1BCHE | |
| SCHEMBL19463085 | 0.79 | ACHE (0.57) | ACHEKDM4EGAABACE1BCHE | |
| SCHEMBL4223535 | 0.79 | SIGMAR1 (0.61) | ACHEHRH3SIGMAR1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3190116-B1 | PYRAZOLOTHIAZOLE COMPOUND AND MEDICINE COMPRISING SAME | NIPPON SHINYAKU CO LTD (JP) | 2020-08-05 | — | — | EP | disclosed |
| US-9999622-B2 | Pyrazolothiazole compound and medicine comprising same | NIPPON SHINYAKU CO., LTD. (JP) | 2018-06-19 | — | — | US | disclosed |
| US-9937176-B2 | Pyrazolothiazole compound and medicine comprising same | NIPPON SHINYAKU CO., LTD. (JP) | 2018-04-10 | — | — | US | disclosed |
| US-20180092919-A1 | PYRAZOLOTHIAZOLE COMPOUND AND MEDICINE COMPRISING SAME | NIPPON SHINYAKU CO., LTD. (JP) | 2018-04-05 | — | — | US | disclosed |
| US-20170252341-A1 | PYRAZOLOTHIAZOLE COMPOUND AND MEDICINE COMPRISING SAME | NIPPON SHINYAKU CO., LTD. (JP) | 2017-09-07 | — | — | US | disclosed |
| EP-3190116-A1 | PYRAZOLOTHIAZOLE COMPOUND AND MEDICINE | Nippon Shinyaku Co., Ltd. (JP) | 2017-07-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180092919-A1 | PYRAZOLOTHIAZOLE COMPOUND AND MEDICINE COMPRISING SAME | JAK1, JAK2, JAK3 | ACHE 4856/4885KDM4E 2848/4885GAA 3808/4885 |
| US-20170252341-A1 | PYRAZOLOTHIAZOLE COMPOUND AND MEDICINE COMPRISING SAME | JAK1, JAK2, JAK3 | ACHE 4856/4885KDM4E 2848/4885GAA 3808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.