Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17721710 | 0.90 | PPARA (0.38) | PPARAPPARGPPARDCA2SMN1; SMN2 | |
| SCHEMBL29840567 | 0.88 | PPARG (0.40) | PPARAPPARGPPARDCA2SMN1; SMN2 | |
| SCHEMBL16929982 | 0.88 | PPARG (0.40) | PPARAPPARGPPARDCA2SMN1; SMN2 | |
| SCHEMBL19252776 | 0.86 | REN (0.46) | PPARAHPGDNPC1MAPTLMNA | |
| SCHEMBL19815542 | 0.81 | PPARA (0.41) | PPARAPPARGPPARDKDM4EMAPK1 | |
| SCHEMBL8285816 | 0.80 | ALDH1A1 (0.43) | SMN1; SMN2HPGDNPC1RAB9AKDM4E | |
| SCHEMBL29840555 | 0.80 | KDM4E (0.41) | PPARAPPARDCA2SMN1; SMN2HPGD | |
| SCHEMBL16930147 | 0.80 | KDM4E (0.41) | PPARAPPARDCA2SMN1; SMN2HPGD | |
| SCHEMBL17709394 | 0.78 | REN (0.45) | PPARAHPGDNPC1MAPTLMNA | |
| SCHEMBL16929923 | 0.77 | CA2 (0.38) | PPARAPPARGPPARDCA2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114812-A1 | COMBINATION THERAPY OF AN HBSAG INHIBITOR AND AN INTERFERON | F. HOFFMANN-LA ROCHE AG (CH) | 2017-07-06 | — | — | WO | disclosed |