Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.56 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.52 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19294780 | 1.00 | TAAR1 (0.56) | TAAR1GABBR2GABBR1HTR2ACHRNB2 | |
| SCHEMBL2086299 | 1.00 | TAAR1 (0.56) | TAAR1GABBR2GABBR1HTR2ACHRNB2 | |
| Hydrochloric Acid SCHEMBL3032167 | 0.98 | TAAR1 (0.54) | TAAR1GABBR2GABBR1HTR2ACHRNB2 | |
| SCHEMBL5699189 | 0.89 | TAAR1 (0.39) | TAAR1GABBR2GABBR1 | |
| SCHEMBL17906493 | 0.88 | CHRNB2 (0.55) | TAAR1GABBR2GABBR1HTR2ACHRNB2 | |
| SCHEMBL21610465 | 0.84 | CTSS (0.47) | TAAR1GABBR2GABBR1HTR2ACHRNB2 | |
| SCHEMBL21610471 | 0.84 | CTSS (0.47) | TAAR1GABBR2GABBR1HTR2ACHRNB2 | |
| SCHEMBL21610473 | 0.84 | CTSS (0.47) | TAAR1GABBR2GABBR1HTR2ACHRNB2 | |
| SCHEMBL1539105 | 0.81 | TAAR1 (0.65) | TAAR1GABBR2GABBR1HTR2ACHRNB2 | |
| SCHEMBL3647917 | 0.81 | ACHE (0.39) | TAAR1GABBR2GABBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | EPIZYME INC (US) | 2021-07-01 | — | — | US | disclosed |
| US-20200048195-A1 | SUBSTITUTED PYRROLIDINE CARBOXAMIDE COMPOUNDS | Epizyme, Inc. | 2020-02-13 | — | — | US | disclosed |
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | disclosed |
| US-10428029-B2 | Isoxazole carboxamide compounds | Epizyme, Inc. (US) | 2019-10-01 | — | — | US | disclosed |
| US-20170362191-A1 | Substituted Cyclohexylamine Compounds | Epizyme, Inc. (US) | 2017-12-21 | — | — | US | disclosed |
| US-20170355695-A1 | SMYD Inhibitors | Epizyme, Inc. (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170247326-A1 | Substituted Pyrrolidine Carboxamide Compounds | Epizyme, Inc. (US) | 2017-08-31 | — | — | US | disclosed |
| US-20170190676-A1 | Isoxazole Carboxamide Compounds | Epizyme, Inc. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428029-B2 | Isoxazole carboxamide compounds | SMYD3, SMYD2, SNRPD3 | TAAR1 4061/4885GABBR2 1934/4885GABBR1 2598/4885 |
| US-20170190676-A1 | Isoxazole Carboxamide Compounds | SMYD3, SMYD2, SNRPD3 | TAAR1 4061/4885GABBR2 1934/4885GABBR1 2598/4885 |
| US-20170355695-A1 | SMYD Inhibitors | SMYD3, SMYD2, SMURF2 | TAAR1 4417/4885GABBR2 1660/4885GABBR1 2425/4885 |
| US-20210198252-A1 | SMYD INHIBITORS | SMYD3, SMYD2, SMURF2 | TAAR1 4421/4885GABBR2 1681/4885GABBR1 2442/4885 |
| US-20170247326-A1 | Substituted Pyrrolidine Carboxamide Compounds | SMYD3, SMYD2, SMURF2 | TAAR1 4268/4885GABBR2 2509/4885GABBR1 3310/4885 |
| US-20170362191-A1 | Substituted Cyclohexylamine Compounds | SMYD3, SMYD2, SNRPD3 | TAAR1 2556/4885GABBR2 3292/4885GABBR1 3910/4885 |
| US-20190322660-A1 | SMYD INHIBITORS | SMYD2, SMYD3, SMURF2 | TAAR1 4320/4885GABBR2 1088/4885GABBR1 1945/4885 |
| US-20200048195-A1 | SUBSTITUTED PYRROLIDINE CARBOXAMIDE COMPOUNDS | SMYD3, SMYD2, SMURF2 | TAAR1 4268/4885GABBR2 2509/4885GABBR1 3310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.