Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.53 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 13/20 | 0.41 |
| ▸ | BCHE | P06276 | 5/20 | 0.41 |
| ▸ | ACHE | P22303 | 5/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19101681 | 0.87 | KDM4C (0.44) | KDM4AKDM4CPHF8 | |
| SCHEMBL19101675 | 0.86 | KDM4C (0.52) | KDM4AKDM4CPHF8 | |
| SCHEMBL16032896 | 0.83 | KDM4C (0.77) | KDM4AKDM4CPHF8 | |
| SCHEMBL19101685 | 0.82 | PHF8 (0.48) | KDM4AKDM4CPHF8MPO | |
| SCHEMBL19101706 | 0.73 | KDM5A (0.67) | KDM4AKDM4CPHF8 | |
| SCHEMBL16033534 | 0.71 | KDM5A (0.65) | KDM4AKDM4C | |
| SCHEMBL16075704 | 0.70 | KDM5A (0.76) | KDM4AKDM4C | |
| SCHEMBL18579584 | 0.69 | KDM4C (0.69) | KDM4AKDM4CPHF8 | |
| SCHEMBL16035020 | 0.69 | KDM4C (1.00) | KDM4AKDM4CPHF8 | |
| SCHEMBL19139044 | 0.69 | KDM2B (0.47) | KDM4AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701657-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2017-07-11 | — | — | US | disclosed |