Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RHOC | P08134 | 2/20 | 0.39 |
| ▸ | RHOA | P61586 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275000 | 0.85 | EPHX2 (0.50) | CXCR3EPHX2NAMPTACP1ALDH1A1 | |
| SCHEMBL4274998 | 0.85 | EPHX2 (0.50) | CXCR3EPHX2NAMPTACP1ALDH1A1 | |
| SCHEMBL19113042 | 0.83 | EPHX2 (0.54) | CXCR3EPHX2NAMPTACP1ALDH1A1 | |
| SCHEMBL4278127 | 0.82 | CXCR3 (0.56) | CXCR3EPHX2NAMPTACP1ALDH1A1 | |
| SCHEMBL20056125 | 0.81 | KCNH2 (0.59) | KCNH2CACNA1I | |
| SCHEMBL1445327 | 0.79 | LMNA (0.52) | CXCR3EPHX2NAMPTACP1ALDH1A1 | |
| SCHEMBL4277997 | 0.78 | CXCR3 (0.55) | CXCR3EPHX2NAMPTACP1ALDH1A1 | |
| SCHEMBL16478290 | 0.78 | EPHX2 (0.46) | CXCR3EPHX2NAMPTALDH1A1GAA | |
| SCHEMBL6863335 | 0.78 | STS (0.56) | CXCR3EPHX2TACR1 | |
| SCHEMBL4271452 | 0.78 | CXCR3 (0.54) | CXCR3EPHX2NAMPTACP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |
| EP-3189839-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Taro Pharmaceuticals Inc. (CA) | 2017-07-12 | — | — | EP | disclosed |