Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPIN1 | Q9Y657 | 2/20 | 0.41 |
| ▸ | SPIN4 | Q56A73 | 1/20 | 0.38 |
| ▸ | SPIN3 | Q5JUX0 | 1/20 | 0.38 |
| ▸ | SPIN2B | Q9BPZ2 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL88770 | 0.85 | PTGS2 (0.48) | PRSS1MEN1KMT2ARXFP1KDM4E | |
| SCHEMBL89710 | 0.85 | L3MBTL1 (0.39) | PRSS1MEN1KMT2ARXFP1MAPT | |
| SCHEMBL90116 | 0.83 | ALOX15 (0.39) | PRSS1MEN1KMT2ARXFP1KDM4E | |
| SCHEMBL89209 | 0.75 | ALDH1A1 (0.51) | MEN1KMT2AKDM4EL3MBTL1TDP1 | |
| SCHEMBL8264192 | 0.72 | MAOB (0.41) | MEN1KMT2AL3MBTL1MAPK1LOX | |
| SCHEMBL24489024 | 0.72 | AOC3 (0.48) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL6943325 | 0.71 | KDM4E (0.51) | PRSS1MEN1KMT2AKDM4EATM | |
| SCHEMBL15599712 | 0.71 | CSNK2A1 (0.45) | SPIN1SPIN4SPIN3SPIN2BKDM4E | |
| SCHEMBL13433964 | 0.71 | L3MBTL1 (0.44) | PRSS1HTR2AMEN1KMT2AMAPT | |
| SCHEMBL8266091 | 0.69 | CSNK2A1 (0.40) | HTR2AHTR2CL3MBTL1MAPK1LOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |