Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15216104 | 0.83 | HSD17B10 (0.48) | ALOX15TSHRHSD17B10KDM4EALDH1A1 | |
| SCHEMBL738198 | 0.82 | SMN1; SMN2 (0.54) | ALOX15TSHRHSD17B10ALDH1A1GAA | |
| SCHEMBL1911488 | 0.82 | ALOX15 (0.62) | ALOX15TSHRHSD17B10KDM4ELMNA | |
| SCHEMBL17547266 | 0.81 | TSHR (0.72) | ALOX15TSHRHSD17B10KDM4ELMNA | |
| SCHEMBL16216045 | 0.81 | HSD17B10 (0.71) | ALOX15TSHRHSD17B10KDM4ELMNA | |
| SCHEMBL31717947 | 0.80 | HSD17B10 (1.00) | ALOX15TSHRHSD17B10KDM4ELMNA | |
| SCHEMBL26981196 | 0.80 | HSD17B10 (0.91) | ALOX15TSHRHSD17B10KDM4ELMNA | |
| SCHEMBL13912231 | 0.80 | SMN1; SMN2 (0.58) | ALOX15TSHRHSD17B10ALDH1A1GAA | |
| SCHEMBL12226466 | 0.80 | HSD17B10 (0.69) | ALOX15TSHRHSD17B10KDM4ELMNA | |
| SCHEMBL14218697 | 0.80 | TSHR (0.69) | ALOX15TSHRHSD17B10KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077787-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2012-03-29 | — | — | US | disclosed |
| US-20120077787-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2012-03-29 | — | — | US | disclosed |
| US-8097617-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-01-17 | — | — | US | disclosed |
| US-20090253689-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077787-A1 | ORGANIC COMPOUNDS | OAT, GPR119, OTC | ALOX15 326/4885TSHR 2009/4885HSD17B10 213/4885 |
| US-20090253689-A1 | Organic Compounds | OAT, GPR119, OTC | ALOX15 326/4885TSHR 2009/4885HSD17B10 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.