Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24339521 | 0.81 | HTR2A (0.49) | HTR7HTR2AHTR2CHTR6MEN1 | |
| SCHEMBL7252893 | 0.77 | HTR6 (0.56) | HTR7HTR6MEN1KMT2APKM | |
| SCHEMBL8259764 | 0.74 | HTR6 (0.40) | HTR6MEN1KMT2APKMHTT | |
| SCHEMBL21515946 | 0.74 | HTT (0.50) | HTR2AHTR2CHTR6MEN1KMT2A | |
| SCHEMBL6741957 | 0.73 | HTR7 (0.45) | HTR7HTR2AHTR2CCDC7CDK2 | |
| SCHEMBL23125776 | 0.72 | FABP4 (0.38) | FABP4 | |
| SCHEMBL21010063 | 0.70 | HTR2A (0.49) | HTR2AHTR2CHTR6HTTL3MBTL1 | |
| SCHEMBL2573218 | 0.70 | MEN1 (0.60) | HTR6MEN1KMT2APKMHTT | |
| SCHEMBL29408218 | 0.70 | MEN1 (0.60) | HTR6MEN1KMT2APKMHTT | |
| SCHEMBL266519 | 0.70 | CYP2A6 (0.53) | HTR7HTR2AHTR2CL3MBTL1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9789118-B2 | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof | NOVARTIS AG (CH) | 2017-10-17 | — | — | US | disclosed |
| WO-2012013716-A1 | BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS | NOVARTIS AG (CH) | 2012-02-02 | — | — | WO | disclosed |
| WO-2006108709-A1 | 3-SULFONYLAMINO-PYRROLIDINE-2-ONE DERIVATIVES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-10-19 | — | — | WO | disclosed |