Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | YTHDF3 | Q7Z739 | 1/20 | 0.31 |
| ▸ | YTHDF1 | Q9BYJ9 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19116608 | 0.92 | BRS3 (0.39) | KDM1ABRS3NPY5RDAOCCR5 | |
| SCHEMBL19521677 | 0.91 | NPY5R (0.44) | KDM1ABRS3NPY5RDAOCCR5 | |
| SCHEMBL19521578 | 0.88 | IDO1 (0.33) | KDM1ABRS3RAB9A | |
| SCHEMBL19521676 | 0.82 | CCR5 (0.33) | BRS3CCR5 | |
| SCHEMBL28576254 | 0.80 | BRS3 (0.35) | KDM1ABRS3NPY5RDAOYTHDF2 | |
| SCHEMBL12685102 | 0.72 | — | — | |
| SCHEMBL19077856 | 0.72 | KDM1A (0.35) | KDM1ANPY5RYTHDF2YTHDF3YTHDF1 | |
| SCHEMBL19087053 | 0.72 | CCNA2 (0.32) | KDM1ANPY5RCCR5CCNA2CDK2 | |
| SCHEMBL15586080 | 0.71 | F10 (0.35) | KDM1ANPY5RMAPT | |
| SCHEMBL22365025 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017120194-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2017-07-13 | — | — | WO | disclosed |