Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATG4B | Q9Y4P1 | 9/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL353121 | 0.90 | ATG4B (0.36) | ATG4BCDK2GSK3AGSK3BRPS6KB1 | |
| SCHEMBL19119508 | 0.88 | KMT2A (0.30) | KMT2A | |
| SCHEMBL19119070 | 0.82 | ATG4B (0.48) | ATG4BCDK2GSK3AGSK3BAURKB | |
| SCHEMBL19119282 | 0.81 | RAB9A (0.33) | NPC1ALDH1A1HTTRAB9AKMT2A | |
| SCHEMBL19119086 | 0.80 | SHMT2 (0.31) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL19119501 | 0.79 | HTT (0.35) | ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL19118721 | 0.79 | S1PR2 (0.36) | MEN1NPC1LMNARAB9AKMT2A | |
| SCHEMBL352627 | 0.79 | ALDH1A1 (0.32) | MEN1ALDH1A1LMNAHTTRAB9A | |
| SCHEMBL19119290 | 0.78 | KMT2A (0.32) | ALDH1A1LMNAHTTRAB9AKMT2A | |
| SCHEMBL353762 | 0.78 | NPC1 (0.37) | ATG4BCDK2GSK3AGSK3BRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | claimed |