Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19096619 | 0.78 | FAAH (0.66) | DYRK1ADYRK1BCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL19096228 | 0.69 | FAAH (0.54) | DYRK1ADYRK1BCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL19096243 | 0.69 | FAAH (0.56) | DYRK1ADYRK1BCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL17302145 | 0.68 | MEN1 (0.62) | DYRK1ADYRK1BCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL24504101 | 0.65 | POLB (0.35) | DYRK1ADYRK1BCA9FAAHALDH1A1 | |
| SCHEMBL17295576 | 0.65 | FAAH (0.57) | DYRK1ADYRK1BCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL17295644 | 0.65 | MEN1 (0.54) | DYRK1ADYRK1BCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL17295646 | 0.65 | MEN1 (0.54) | DYRK1ADYRK1BCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL17295574 | 0.65 | FAAH (0.57) | DYRK1ADYRK1BCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL19096226 | 0.65 | CA9 (0.62) | DYRK1ADYRK1BCSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170197952-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | UNIVERSITAT BERN (CH) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197952-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | GRIN2B, IL1B, GRIA4 | DYRK1A 2060/4885DYRK1B 1960/4885CSNK2A2 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.