Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | RHOC | P08134 | 2/20 | 0.37 |
| ▸ | RHOA | P61586 | 2/20 | 0.37 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11984113 | 0.84 | IDO1 (0.52) | IDO1TACR1CYP3A4CYP2D6TSHR | |
| SCHEMBL17062167 | 0.81 | IDO1 (0.41) | IDO1TACR1SLC6A4KCNH2RAPGEF4 | |
| SCHEMBL630541 | 0.79 | RXRA (0.45) | IDO1TACR1SLC6A4KCNH2RAPGEF4 | |
| SCHEMBL257077 | 0.79 | RAPGEF4 (0.41) | IDO1TACR1SLC6A4KCNH2RAPGEF4 | |
| SCHEMBL15516391 | 0.79 | SLC13A3 (0.40) | IDO1TACR1SLC6A4KCNH2RAPGEF4 | |
| SCHEMBL5730059 | 0.79 | IDO1 (0.44) | IDO1TACR1SLC6A4KCNH2RAPGEF4 | |
| SCHEMBL1229494 | 0.79 | IDO1 (0.39) | IDO1TACR1SLC6A4KCNH2RAPGEF4 | |
| SCHEMBL30302522 | 0.79 | IDO1 (0.44) | IDO1TACR1SLC6A4KCNH2RAPGEF4 | |
| SCHEMBL321756 | 0.77 | AHR (0.52) | IDO1RAPGEF4SLC13A3AHRCYP3A4 | |
| SCHEMBL3786224 | 0.77 | RAPGEF4 (0.47) | IDO1RAPGEF4RHOCRHOASLC13A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404901-A1 | 1,2-Disubstituted 4-benzylamino-pyrrolidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis | Novartis AG (CH) | 2012-01-11 | — | — | EP | disclosed |
| WO-2009071509-A1 | 1,2-DISUBSTITUTED-4-BENZYLAMINO-PYRROLIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLI PIDEMIA OR ARTERIOSCLEROSIS | NOVARTIS AG (CH) | 2009-06-11 | — | — | WO | disclosed |