Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913587 | 0.78 | CDK2 (0.48) | MTORPIK3CAPIK3CBPIK3CGCDK5 | |
| SCHEMBL6898700 | 0.75 | MTOR (0.62) | MTORPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1913382 | 0.70 | PIK3CA (0.60) | MTORPIK3CAPIK3CBPIK3CGCDK5 | |
| SCHEMBL1803512 | 0.68 | XDH (0.50) | MTORPIK3CAPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL20740567 | 0.65 | CDK5 (0.42) | MTORPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1578336 | 0.63 | ADORA2A (0.51) | ADORA2AADORA1 | |
| SCHEMBL23547316 | 0.62 | DAPK1 (0.38) | MTORPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL27405153 | 0.62 | ADORA1 (0.41) | MTORPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL19366633 | 0.59 | ALDH1A1 (0.41) | MTORPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL15742024 | 0.58 | EGFR (0.45) | CDK5DYRK1ACDK5R1CSNK1ECLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011078795-A1 | BRIDGED MORPHOLINO SUBSTITUTED PURINES | S*BIO PTE LTD (SG) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011078795-A1 | BRIDGED MORPHOLINO SUBSTITUTED PURINES | S*BIO PTE LTD (SG) | 2011-06-30 | — | — | WO | disclosed |