Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.38 |
| ▸ | FYN | P06241 | 3/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17404677 | 0.70 | PIK3CA (0.45) | PIK3CASMARCA2SMARCA4PBRM1ALK | |
| SCHEMBL31173935 | 0.70 | ALK (0.50) | PIK3CASMARCA2SMARCA4PBRM1ALK | |
| SCHEMBL25192257 | 0.70 | ALK (0.50) | PIK3CASMARCA2SMARCA4PBRM1ALK | |
| SCHEMBL20293532 | 0.67 | GPR119 (0.57) | SMARCA2SMARCA4PBRM1PTPN11CKS1B | |
| SCHEMBL30796360 | 0.66 | SMARCA2 (0.58) | PIK3CASMARCA2SMARCA4PBRM1ALK | |
| SCHEMBL1707770 | 0.64 | MAPT (0.57) | SMARCA2SMARCA4PBRM1ALKPDK2 | |
| SCHEMBL30431090 | 0.64 | LMNA (0.44) | ALKPDK2GPR119 | |
| SCHEMBL28534844 | 0.64 | LMNA (0.44) | ALKPDK2GPR119 | |
| SCHEMBL21045603 | 0.63 | TRPC6 (0.56) | PIK3CASMARCA2SMARCA4PBRM1ALK | |
| SCHEMBL30419595 | 0.63 | TRPC6 (0.56) | PIK3CASMARCA2SMARCA4PBRM1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708295-B2 | Substituted 2-aminopyridine protein kinase inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2017-07-18 | — | — | US | disclosed |