Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DTYMK | P23919 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31482906 | 1.00 | TSHR (0.45) | TSHRALDH1A1MEN1KMT2ADTYMK | |
| SCHEMBL27772700 | 0.89 | TSHR (0.46) | TSHRALDH1A1DTYMKL3MBTL1POLB | |
| SCHEMBL38666634 | 0.88 | TSHR (0.49) | TSHRALDH1A1MEN1KMT2ADTYMK | |
| Hydrochloric Acid SCHEMBL10553172 | 0.83 | KEAP1 (0.51) | TSHRALDH1A1DTYMKKEAP1NFE2L2 | |
| SCHEMBL707784 | 0.83 | PDGFRB (0.49) | TSHRALDH1A1MEN1KMT2AL3MBTL1 | |
| Nitrous Acid SCHEMBL27793944 | 0.83 | TSHR (0.42) | TSHRALDH1A1DTYMKL3MBTL1POLB | |
| SCHEMBL1317569 | 0.81 | ALDH1A1 (0.41) | TSHRALDH1A1DTYMKTDP1KEAP1 | |
| SCHEMBL8832668 | 0.79 | TSHR (0.46) | TSHRDTYMKL3MBTL1POLBTDP1 | |
| SCHEMBL12489104 | 0.79 | TSHR (0.46) | TSHRALDH1A1DTYMKL3MBTL1POLB | |
| SCHEMBL8832665 | 0.79 | TSHR (0.46) | TSHRDTYMKL3MBTL1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365558-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2023-11-16 | — | — | US | disclosed |
| EP-4219461-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF | Medshine Discovery Inc. (CN) | 2023-08-02 | — | — | EP | disclosed |
| US-11001569-B2 | 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-05-11 | — | — | US | disclosed |
| US-20200138827-A1 | SMALL MOLECULE MODULATORS OF HUMAN STING | CURADEV PHARMA LIMITED (GB) | 2020-05-07 | — | — | US | disclosed |
| EP-3642184-A1 | SMALL MOLECULE MODULATORS OF HUMAN STING | Curadev Pharma Limited (GB) | 2020-04-29 | — | — | EP | disclosed |
| US-20200109129-A1 | NEW 6-MEMBERED HETEROAROMATIC SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN-CILAG (FR) | 2020-04-09 | — | — | US | disclosed |
| WO-2019243823-A1 | AZAHETEROCYCLIC SMALL MOLECULE MODULATORS OF HUMAN STING | CURADEV PHARMA LIMITED (GB) | 2019-12-26 | — | — | WO | disclosed |
| WO-2018234805-A1 | SMALL MOLECULE MODULATORS OF HUMAN STING | CURADEV PHARMA LIMITED (GB) | 2018-12-27 | — | — | WO | disclosed |
| EP-3405464-A1 | NEW 6-MEMBERED HETEROAROMATIC SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | Janssen Pharmaceutica NV (BE) | 2018-11-28 | — | — | EP | disclosed |
| WO-2017125534-A1 | NEW 6-MEMBERED HETEROAROMATIC SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200138827-A1 | SMALL MOLECULE MODULATORS OF HUMAN STING | STING1, IRF3, CGAS | TSHR 4220/4885ALDH1A1 4755/4885MEN1 3114/4885 |
| US-11001569-B2 | 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors | NFKBIA, MAP3K14, IKBKG | TSHR 4112/4885ALDH1A1 3944/4885MEN1 2516/4885 |
| US-20230365558-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF | CYP3A7, UGT2B7, SFPQ | TSHR 2694/4885ALDH1A1 1495/4885MEN1 995/4885 |
| US-20200109129-A1 | NEW 6-MEMBERED HETEROAROMATIC SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | NFKBIA, MAP3K14, IKBKG | TSHR 4129/4885ALDH1A1 3971/4885MEN1 2327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.