Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14960629 | 0.83 | SOST (0.54) | SOSTNAMPTCYP2C9PIK3CAMAPK1 | |
| SCHEMBL19116551 | 0.83 | SOST (0.49) | SOSTNAMPTCYP2C9PIK3CASMN1; SMN2 | |
| SCHEMBL14960630 | 0.81 | SOST (0.52) | SOSTNAMPTCYP2C9PIK3CASMN1; SMN2 | |
| SCHEMBL19151037 | 0.80 | LMNA (0.49) | CYP2C9SMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL25587537 | 0.79 | SOST (0.51) | SOSTNAMPTCYP2C9PIK3CAMAPK1 | |
| SCHEMBL12320561 | 0.77 | HPGD (0.68) | SOSTNAMPTCYP2C9PIK3CASMN1; SMN2 | |
| SCHEMBL30259908 | 0.76 | ALDH1A1 (0.64) | SMN1; SMN2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13170238 | 0.76 | ALDH1A1 (0.64) | SMN1; SMN2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL16181507 | 0.76 | NAMPT (0.49) | SOSTNAMPTCYP2C9PIK3CARAB9A | |
| SCHEMBL7848367 | 0.75 | NAMPT (0.70) | NAMPTCYP2C9NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3402785-B1 | 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2020-02-26 | — | — | EP | disclosed |
| WO-2017121649-A1 | 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2017-07-20 | — | — | WO | disclosed |