Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603994 | 0.79 | CHRM5 (0.44) | HRH2HRH1LMNAMAPTCHRM5 | |
| SCHEMBL9986402 | 0.76 | FAAH (0.65) | FAAHCNR1CNR2LMNAEPHX2 | |
| SCHEMBL27879559 | 0.76 | LMNA (0.66) | FAAHCNR1CNR2LMNAEPHX2 | |
| SCHEMBL9958885 | 0.76 | LMNA (0.66) | FAAHCNR1CNR2LMNAEPHX2 | |
| SCHEMBL22534407 | 0.76 | FAAH (0.60) | FAAHCNR1CNR2LMNAEPHX2 | |
| SCHEMBL27918401 | 0.76 | FAAH (0.65) | FAAHCNR1CNR2LMNAEPHX2 | |
| SCHEMBL8362073 | 0.76 | FAAH (0.60) | FAAHCNR1CNR2LMNAEPHX2 | |
| SCHEMBL6606038 | 0.76 | HRH2 (0.54) | HRH2HRH1SIGMAR1LMNAGNAI3 | |
| Hydrochloric Acid SCHEMBL31722504 | 0.74 | HRH2 (0.53) | HRH2HRH1SIGMAR1LMNAGNAI3 | |
| SCHEMBL2597710 | 0.74 | CHRM5 (0.40) | HRH2HRH1SIGMAR1CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3196200-B1 | 2-AMINOTHIAZOLE DERIVATIVES OR SALT THEREOF AS MUSCARINIC M3 LIGANDS FOR THE TREATMENT OF BLADDER DISEASES | ASTELLAS PHARMA INC (JP) | 2019-05-08 | — | — | EP | disclosed |
| EP-3196200-A1 | 2-AMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2017-07-26 | — | — | EP | disclosed |