Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14012690 | 0.92 | CHRM5 (0.39) | CHRM5CHRM3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16062677 | 0.87 | LMNA (0.39) | CHRM5CHRM3SMN1; SMN2MEN1KMT2A | |
| Pyridine SCHEMBL28218072 | 0.87 | KDM4E (0.38) | CHRM5CHRM3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20762100 | 0.82 | TP53 (0.51) | SMN1; SMN2LMNAALDH1A1TSHRCYP2D6 | |
| SCHEMBL28859833 | 0.82 | ALDH1A1 (0.52) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL1418067 | 0.82 | CHRM5 (0.54) | CHRM5CHRM3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14197235 | 0.81 | GLA (0.55) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL6603043 | 0.80 | SMN1; SMN2 (0.56) | CHRM5CHRM3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19450983 | 0.80 | CHRM5 (0.41) | CHRM5CHRM3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19156830 | 0.79 | FAAH (0.45) | CHRM5CHRM3LMNAALDH1A1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741133-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| US-6455529-B1 | OXAZOLIDIN-2-ONE DERIVATIVES; ANTICOAGULANTS; ANTIMETASTASIS, ANTICARCINOGENIC, ANTIISCHEMIC, AND ANTIINFLAMMATORY AGENTS; OSTEOPOROSIS, ARTERIOSCLEROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-09-24 | — | — | US | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |