Sugi Predict

Sugi Predict / Compounds / SCHEMBL191585

SCHEMBL191585

SCHEMBL191585

CSc1nc(N)cc(Cl)n1

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 6/20 0.49
▸ MEN1 O00255 4/20 0.49
▸ POLB P06746 2/20 0.46
▸ GAA P10253 2/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ HTT P42858 1/20 0.42
▸ HSP90AB1 P08238 2/20 0.39
▸ HSP90AA1 P07900 3/20 0.39
▸ RAB9A P51151 2/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ KDM4E B2RXH2 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29368005 1.00 KMT2A (0.49) KMT2AMEN1POLBGAASMN1; SMN2
Hydrochloric Acid SCHEMBL11426179 0.98 KMT2A (0.47) KMT2AMEN1POLBGAASMN1; SMN2
SCHEMBL3625881 0.84 HSP90AB1 (0.46) KMT2AMEN1POLBSMN1; SMN2HSP90AB1
SCHEMBL62021 0.84 POLB (0.53) KMT2AMEN1POLBGAASMN1; SMN2
SCHEMBL8018804 0.76 KMT2A (0.49) KMT2AMEN1POLBGAAHTT
SCHEMBL30718977 0.76 KMT2A (0.49) KMT2AMEN1POLBGAAHTT
SCHEMBL1902046 0.76 POLB (0.47) KMT2AMEN1POLBGAASMN1; SMN2
SCHEMBL13741276 0.74 CDK2 (0.37) KMT2AMEN1POLBGAASMN1; SMN2
SCHEMBL3110403 0.74 KMT2A (0.51) KMT2AMEN1POLBGAASMN1; SMN2
SCHEMBL163966 0.74 HSP90AB1 (0.39) KMT2AMEN1POLBGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 483 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116082308-B Degradation agent and preparation method and application thereof 合肥综合性国家科学中心大健康研究院 2023-12-22 — — CN claimed
CN-116082308-A Degradation agent and preparation method and application thereof 合肥综合性国家科学中心大健康研究院 2023-05-09 — — CN claimed
US-7547713-B2 O-pyridinequinone derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives GU LIANQUAN 2009-06-16 — — US claimed
CN-1284773-C Ortho-pyridinequinone derivative, composite containing said derivative, its preparation method and application BAIRUI GLOBAL CO LTD (VG) 2006-11-15 — — CN claimed
US-20060111405-A1 O-pyridinequinone derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives GU LIANQUAN 2006-05-25 — — US claimed
CN-1477099-A O-pyridinoquinone derivative, composition containing the same, preparation method and use of the same 百瑞全球有限公司 2004-02-25 — — CN claimed
EP-1012146-B1 HIV NUCLEAR LOCALIZATION INHIBITORS PICOWER INST MED RES (US) 2003-07-30 — — EP claimed
EP-1012146-A4 HIV NUCLEAR LOCALIZATION INHIBITORS PICOWER INST MED RES (US) 2002-12-04 — — EP claimed
EP-1012146-A1 HIV NUCLEAR LOCALIZATION INHIBITORS THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) 2000-06-28 — — EP claimed
WO-1999009014-A1 HIV NUCLEAR LOCALIZATION INHIBITORS THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) 1999-02-25 — — WO claimed
US-5808068-A HIV nuclear localization inhibitors THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) 1998-09-15 — — US claimed
US-12612387-B2 RAS inhibitors and methods of using the same JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) 2026-04-28 — — US disclosed
US-20260028346-A1 BTK DEGRADER AND USE THEREOF ASCENTAGE PHARMA SUZHOU CO LTD (CN) 2026-01-29 — — US disclosed
US-20260028345-A1 BTK DEGRADER AND USE THEREOF ASCENTAGE PHARMA SUZHOU CO LTD (CN) 2026-01-29 — — US disclosed
US-20250313567-A1 IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES AS A2A / A2B INHIBITORS INCYTE CORPORATION 2025-10-09 — — US disclosed
US-4503050-A BRONCHODILATORS RIKER LABORATORIES, INC. (US) 1985-03-05 — — US disclosed
EP-0128006-A2 A soil-disease-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-12-12 — — EP disclosed
EP-0126254-A1 N-(2-nitrophenyl)-4-aminopyrimidine derivatives as microbicides CIBA-GEIGY AG (CH) 1984-11-28 — — EP disclosed
EP-0100899-A2 Benzisoselenazolones, process for their preparation and pharmaceutical compositions containing them A. Nattermann & Cie. GmbH (DE) 1984-02-22 — — EP disclosed
US-4199583-A 4-AMINO-6-HALO-2-METHYLTHIO-, METHOXY-, METHYLSULFINYL- OR METHYLSULFONYL-PYRIMIDINES THE UPJOHN COMPANY (US) 1980-04-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028345-A1 BTK DEGRADER AND USE THEREOF BTK, SYK, TEC KMT2A 1248/4885MEN1 2718/4885POLB 4375/4885
US-20060111405-A1 O-pyridinequinone derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives PTGS2, PTGES2, PTGES KMT2A 2390/4885MEN1 4566/4885POLB 1417/4885
US-20260028346-A1 BTK DEGRADER AND USE THEREOF BTK, SYK, LYN KMT2A 1003/4885MEN1 2299/4885POLB 4483/4885
US-12612387-B2 RAS inhibitors and methods of using the same KRAS, NRAS, HRAS KMT2A 3550/4885MEN1 2308/4885POLB 2217/4885
US-20250313567-A1 IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES AS A2A / A2B INHIBITORS ADORA2A, ADORA2B, ADORA1 KMT2A 1923/4885MEN1 3806/4885POLB 1465/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.