Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 3/20 | 0.56 |
| ▸ | GUSB | P08236 | 6/20 | 0.56 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25722414 | 0.87 | HPSE (0.64) | GUSBNPBWR1NPC1RAB9ACHEK2 | |
| SCHEMBL25722406 | 0.85 | NPBWR1 (0.55) | RHEBGUSBNPBWR1NPC1RAB9A | |
| SCHEMBL13041693 | 0.85 | NPBWR1 (0.64) | NPBWR1NPC1RAB9ACHEK2MEN1 | |
| SCHEMBL17268742 | 0.83 | MEN1 (0.47) | RHEBGUSBNPC1RAB9AMEN1 | |
| SCHEMBL21087323 | 0.81 | NPC1 (0.55) | GUSBNPBWR1NPC1RAB9ACHEK2 | |
| SCHEMBL19168082 | 0.81 | NPBWR1 (0.57) | GUSBNPBWR1NPC1RAB9ACHEK2 | |
| SCHEMBL19167944 | 0.81 | NPBWR1 (0.55) | RHEBGUSBNPBWR1CHEK2ALDH1A1 | |
| SCHEMBL19166948 | 0.81 | TRPV1 (0.58) | RHEBGUSBNPBWR1CHEK2HPSE | |
| SCHEMBL3333916 | 0.81 | GUSB (0.79) | GUSBNPBWR1NPC1RAB9ACHEK2 | |
| SCHEMBL19166950 | 0.80 | SIRT2 (0.55) | RHEBGUSBNPBWR1CHEK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170210741-A1 | Benzimidazole Compounds, Use As Inhibitors of WNT Signaling Pathway in Cancers, and Methods for Preparation Thereof | SOUTHERN RESEARCH INSTITUTE | 2017-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210741-A1 | Benzimidazole Compounds, Use As Inhibitors of WNT Signaling Pathway in Cancers, and Methods for Preparation Thereof | WNT1, WNT3, CTNNB1 | RHEB 1379/4885GUSB 2835/4885NPBWR1 3481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.