Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.55 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.54 |
| ▸ | CCR2 | P41597 | 1/20 | 0.52 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RHEB | Q15382 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TOP1 | P11387 | 2/20 | 0.46 |
| ▸ | TOP2A | P11388 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19167944 | 0.99 | NPBWR1 (0.55) | SIRT2SIRT1NPBWR1CCR2PRKAG1 | |
| SCHEMBL19137947 | 0.90 | CCR2 (0.58) | SIRT2SIRT1NPBWR1CCR2PRKAG1 | |
| SCHEMBL19198151 | 0.90 | SIRT2 (0.59) | SIRT2SIRT1NPBWR1AURKADGAT1 | |
| SCHEMBL19175932 | 0.89 | DGAT1 (0.59) | DGAT1SOAT1KCNH2POLBSMN1; SMN2 | |
| SCHEMBL19137938 | 0.89 | NPBWR1 (0.59) | SIRT2SIRT1NPBWR1CCR2PRKAG1 | |
| SCHEMBL19137928 | 0.82 | DGAT1 (0.52) | SIRT2SIRT1NPBWR1CCR2PRKAG1 | |
| SCHEMBL19137959 | 0.81 | NPBWR1 (0.55) | SIRT2SIRT1NPBWR1CCR2PRKAG1 | |
| SCHEMBL19175989 | 0.81 | SIRT2 (0.55) | SIRT2SIRT1NPBWR1AURKADGAT1 | |
| SCHEMBL19137958 | 0.81 | DGAT1 (0.53) | SIRT2SIRT1NPBWR1CCR2PRKAG1 | |
| SCHEMBL19166933 | 0.80 | RHEB (0.56) | NPBWR1GUSBRHEBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170210741-A1 | Benzimidazole Compounds, Use As Inhibitors of WNT Signaling Pathway in Cancers, and Methods for Preparation Thereof | SOUTHERN RESEARCH INSTITUTE | 2017-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210741-A1 | Benzimidazole Compounds, Use As Inhibitors of WNT Signaling Pathway in Cancers, and Methods for Preparation Thereof | WNT1, WNT3, CTNNB1 | SIRT2 2195/4885SIRT1 1958/4885NPBWR1 3481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.