Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | JMJD6 | Q6NYC1 | 3/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248952 | 0.94 | TSHR (0.47) | TSHRGAAALDH1A1ACACBKLKB1 | |
| SCHEMBL28363345 | 0.92 | ALDH1A1 (0.36) | TSHRGAAALDH1A1ACACBJMJD6 | |
| SCHEMBL21126224 | 0.92 | TSHR (0.42) | TSHRALDH1A1TDP1L3MBTL1TP53 | |
| SCHEMBL15280688 | 0.89 | CYP11B1 (0.32) | TSHRGAAACACBCYP11B1CYP11B2 | |
| SCHEMBL28359952 | 0.89 | LMNA (0.47) | TSHRALDH1A1JMJD6TDP1MAPK1 | |
| SCHEMBL19186 | 0.89 | JMJD6 (0.44) | TSHRGAAALDH1A1JMJD6ADORA3 | |
| SCHEMBL28359954 | 0.88 | TSHR (0.42) | TSHRALDH1A1TDP1L3MBTL1TP53 | |
| SCHEMBL596089 | 0.85 | GAA (0.40) | GAAALDH1A1ACACBL3MBTL1IRAK4 | |
| SCHEMBL28359973 | 0.84 | PAX8 (0.48) | GAAJMJD6TDP1L3MBTL1MEN1 | |
| SCHEMBL15282392 | 0.84 | CYP3A4 (0.46) | TSHRGAAALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498695-B1 | METHOD FOR SYNTHESIZING 3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID | ZHEJIANG YONGTAI TECHNOLOGY CO LTD (CN) | 2020-12-09 | — | — | EP | disclosed |
| US-10556868-B2 | Method for synthesizing 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid and intermediates thereof | ZHEJIANG YONGTAI TECHNOLOGY CO., LTD. (CN) | 2020-02-11 | — | — | US | disclosed |
| US-20190202791-A1 | METHOD FOR SYNTHESIZING 3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID AND INTERMEDIATES THEREOF | ZHEJIANG YONGTAI TECHNOLOGY CO., LTD. (CN) | 2019-07-04 | — | — | US | disclosed |
| EP-3498695-A1 | METHOD FOR SYNTHESIZING 3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID, AND INTERMEDIATES THEREOF | Zhejiang Yongtai Technology Co., Ltd. (CN) | 2019-06-19 | — | — | EP | disclosed |
| US-8680337-B2 | Process for the production of amides | Sungenta Limited (GB) | 2014-03-25 | — | — | US | disclosed |
| US-8680337-B2 | Process for the production of amides | Sungenta Limited (GB) | 2014-03-25 | — | — | US | disclosed |
| EP-2253623-B1 | New crystal form of a pyrazole fungicide | SYNGENTA PARTICIPATIONS AG (CH) | 2013-10-23 | — | — | EP | disclosed |
| EP-2253623-B1 | New crystal form of a pyrazole fungicide | SYNGENTA PARTICIPATIONS AG (CH) | 2013-10-23 | — | — | EP | disclosed |
| US-20130253225-A1 | PROCESS FOR THE PRODUCTION OF AMIDES | SYNGENTA LIMITED (GB) | 2013-09-26 | — | — | US | disclosed |
| US-8436037-B2 | Process for the production of amides | SYNGENTA LIMITED (GB) | 2013-05-07 | — | — | US | disclosed |
| EP-2253623-A1 | New crystal form of a pyrazole fungicide | Syngenta Participations AG. (CH) | 2010-11-24 | — | — | EP | disclosed |
| EP-2253623-A1 | New crystal form of a pyrazole fungicide | Syngenta Participations AG. (CH) | 2010-11-24 | — | — | EP | disclosed |
| EP-2253622-A1 | Process for the production of amides | Syngenta Participations AG. (CH) | 2010-11-24 | — | — | EP | disclosed |
| EP-2253622-A1 | Process for the production of amides | Syngenta Participations AG. (CH) | 2010-11-24 | — | — | EP | disclosed |
| US-20090163569-A1 | PROCESS FOR THE PRODUCTION OF AMIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090163569-A1 | PROCESS FOR THE PRODUCTION OF AMIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090163569-A1 | PROCESS FOR THE PRODUCTION OF AMIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| EP-1928838-A1 | PROCESS FOR THE PRODUCTION OF AMIDES | Syngeta Participations AG (CH) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007031323-A1 | PROCESS FOR THE PRODUCTION OF AMIDES | SYNGENTA PARTICIPATIONS AG. (CH) | 2007-03-22 | — | — | WO | disclosed |
| WO-2007031323-A1 | PROCESS FOR THE PRODUCTION OF AMIDES | SYNGENTA PARTICIPATIONS AG. (CH) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190202791-A1 | METHOD FOR SYNTHESIZING 3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID AND INTERMEDIATES THEREOF | AFF4, AFF1, AFF2 | TSHR 1411/4885GAA 2440/4885ALDH1A1 30/4885 |
| US-10556868-B2 | Method for synthesizing 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid and intermediates thereof | AFF1, AFF4, AFF2 | TSHR 1207/4885GAA 2184/4885ALDH1A1 32/4885 |
| US-20130253225-A1 | PROCESS FOR THE PRODUCTION OF AMIDES | CFH, C5, CFB | TSHR 92/4885GAA 4495/4885ALDH1A1 1322/4885 |
| US-20090163569-A1 | PROCESS FOR THE PRODUCTION OF AMIDES | C5, CFH, C9 | TSHR 89/4885GAA 4620/4885ALDH1A1 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.