Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14847029 | 1.00 | TRPV6 (0.48) | TRPV6ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22430869 | 0.88 | ALDH1A1 (0.55) | TRPV6ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14846592 | 0.85 | SIGMAR1 (0.49) | ALDH1A1KDM4EMEN1KMT2AL3MBTL3 | |
| SCHEMBL19191784 | 0.84 | SIGMAR1 (0.50) | ALDH1A1KDM4EMEN1KMT2AL3MBTL3 | |
| SCHEMBL14847047 | 0.84 | SIGMAR1 (0.50) | ALDH1A1KDM4EMEN1KMT2AL3MBTL3 | |
| SCHEMBL14847083 | 0.81 | HRH3 (0.47) | ALDH1A1HRH3SMN1; SMN2HTTIDH1 | |
| SCHEMBL24307315 | 0.81 | ALDH1A1 (0.61) | ALDH1A1KDM4EMEN1KMT2AHRH3 | |
| SCHEMBL21378560 | 0.81 | LMNA (0.64) | ALDH1A1KDM4EHRH3 | |
| SCHEMBL19778598 | 0.81 | LMNA (0.64) | ALDH1A1KDM4EHRH3 | |
| SCHEMBL15960142 | 0.81 | LMNA (0.64) | ALDH1A1KDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771337-B1 | 3-(PYRIMIDIN-4-YL)-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH | NOVARTIS AG (CH) | 2017-08-02 | — | — | EP | disclosed |