Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.59 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.58 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | GUSB | P08236 | 4/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TOP1 | P11387 | 2/20 | 0.49 |
| ▸ | TOP2A | P11388 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19166950 | 0.90 | SIRT2 (0.55) | SIRT2SIRT1NPBWR1AURKAACHE | |
| SCHEMBL19167944 | 0.88 | NPBWR1 (0.55) | SIRT2SIRT1NPBWR1AURKAACHE | |
| SCHEMBL19175989 | 0.85 | SIRT2 (0.55) | SIRT2SIRT1NPBWR1AURKAACHE | |
| SCHEMBL24075401 | 0.84 | NPBWR1 (0.58) | SIRT2SIRT1NPBWR1AURKAACHE | |
| SCHEMBL19137947 | 0.84 | CCR2 (0.58) | SIRT2SIRT1NPBWR1AURKAACHE | |
| SCHEMBL24347820 | 0.84 | NPBWR1 (0.55) | SIRT2SIRT1NPBWR1AURKAACHE | |
| SCHEMBL19137938 | 0.82 | NPBWR1 (0.59) | SIRT2SIRT1NPBWR1AURKAACHE | |
| SCHEMBL17370975 | 0.80 | NPBWR1 (0.54) | SIRT2SIRT1NPBWR1AURKAACHE | |
| SCHEMBL19175931 | 0.79 | DGAT1 (0.62) | ACHEDGAT1SOAT1KCNH2TOP1 | |
| SCHEMBL19175932 | 0.79 | DGAT1 (0.59) | ACHEDGAT1SOAT1KCNH2TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017132511-A1 | BENZIMIDAZOLE COMPOUNDS, USE AS INHIBITORS OF WNT SIGNALING PATHWAY IN CANCERS, AND METHODS FOR PREPARATION THEREOF | SOUTHERN RESEARCH INSTITUTE (US) | 2017-08-03 | — | — | WO | disclosed |