SCHEMBL19199065

SCHEMBL19199065

CC(C)n1nnc2c1-c1ccccc1N(C)Cc1ccccc1-2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 1/20 0.37
MAP3K5 Q99683 1/20 0.37
ALDH1A1 P00352 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP2C19 P33261 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
BRD4 O60885 2/20 0.33
BRD2 P25440 2/20 0.33
BRD3 Q15059 2/20 0.33
CHRM2 P08172 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33
CHRM1 P11229 1/20 0.33
DRD1 P21728 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
ADRA1A P35348 1/20 0.33
OPRM1 P35372 1/20 0.33
DRD3 P35462 1/20 0.33
SLC6A3 Q01959 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18067345 0.95 MAP3K5 (0.37) TOP2AMAP3K5ALDH1A1CYP1A2CYP2C19
SCHEMBL23171525 0.87 MAP3K5 (0.34) MAP3K5CYP1A2CYP2C19MEN1KMT2A
SCHEMBL17992586 0.86 MAP3K5 (0.37) TOP2AMAP3K5ALDH1A1CYP1A2CYP2C19
SCHEMBL19199895 0.85 MAP3K5 (0.36) TOP2AMAP3K5ALDH1A1CYP1A2CYP2C19
SCHEMBL22643768 0.85 MAP3K5 (0.36) TOP2AMAP3K5ALDH1A1CYP1A2CYP2C19
SCHEMBL24252206 0.85
SCHEMBL16856403 0.85 SLC9A1 (0.34) TOP2ASMN1; SMN2BRD4BRD2BRD3
SCHEMBL23837204 0.84 MAP3K5 (0.31) MAP3K5
SCHEMBL21901839 0.84 NPY5R (0.38) TOP2AMAP3K5ALDH1A1CYP1A2CYP2C19
SCHEMBL24496849 0.84 ADRA2A (0.30) ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024044780-A1 INTERLEUKIN-18 VARIANTS AND USES THEREOF SUTRO BIOPHARMA, INC. (US) 2024-02-29 WO disclosed
WO-2024015229-A1 PROTEASE/ENZYME CLEAVABLE LINKER-PAYLOADS AND PROTEIN CONJUGATES SUTRO BIOPHARMA, INC. (US) 2024-01-18 WO disclosed
US-20230330248-A1 ANTIBODY-DRUG CONJUGATE INCLUDING NOVEL CYCLIC DINUCLEOTIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-10-19 US disclosed
US-11583590-B2 Antibody-pyrrolobenzodiazepine derivative conjugate and method of use thereof for treating a tumor DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-02-21 US disclosed
US-11572411-B2 Anti-CD117 antibodies and conjugates Magenta Therapeutics, Inc. (US) 2023-02-07 US disclosed
US-11572370-B2 CD16A binding agents and uses thereof BIOHAVEN THERAPEUTICS LTD. (US) 2023-02-07 US disclosed
US-20220249683-A1 T-CELL DEPLETING THERAPIES HEIDELBERG PHARMA RESEARCH GMBH (DE) 2022-08-11 US disclosed
US-20220177577-A1 ANTI-CD117 ANTIBODY DRUG CONJUGATES AND USES THEREOF Magenta Therapeutics, Inc. 2022-06-09 US disclosed
US-20220175944-A1 ANTI-CD117 ANTIBODY-DRUG CONJUGATES AND USES THEREOF Magenta Therapeutics, Inc. 2022-06-09 US disclosed
US-20220175946-A1 CONDITIONING METHODS FOR GENE THERAPY REGENERON PHARMACEUTICALS, INC. 2022-06-09 US disclosed
US-20200376135-A1 FC SILENCED ANTIBODY DRUG CONJUGATES (ADCS) AND USES THEREOF Magenta Therapeutics, Inc. (US) 2020-12-03 US disclosed
US-20200368363-A1 COMPOSITIONS AND METHODS FOR THE DEPLETION OF CD2+ CELLS MAGENTA THEERAPEUTICS, INC. (US) 2020-11-26 US disclosed
WO-2020221744-A1 METHOD FOR RADIOIODINATION OR RADIOASTATINATION OF A BIOMOLECULE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2020-11-05 WO disclosed
US-20200276326-A1 COMPOSITIONS AND METHODS FOR THE DEPLETION OF CD5+ CELLS MAGENTA THERAPEUTICS INC (US) 2020-09-03 US disclosed
US-20200255523-A1 FC SILENCED ANTIBODY DRUG CONJUGATES (ADCS) AND USES THEREOF REGENERON PHARMACEUTICALS, INC. 2020-08-13 US disclosed
US-20200207859-A1 METHODS OF USING ANTI-CD74 ANTIBODIES AND ANTIBODY CONJUGATES IN TREATMENT OF T-CELL LYMPHOMA SUTRO BIOPHARMA, INC. 2020-07-02 US disclosed
WO-2019136442-A1 CD16A BINDING AGENTS AND USES THEREOF KLEO PHARMACEUTICALS, INC. (US) 2019-07-11 WO disclosed
WO-2019023316-A1 METHODS OF USING ANTI-CD74 ANTIBODIES AND ANTIBODY CONJUGATES IN TREATMENT OF T-CELL LYMPHOMA SUTRO BIOPHARMA, INC. (US) 2019-01-31 WO disclosed
WO-2017132615-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI-CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES SUTRO BIOPHARMA, INC. (US) 2017-08-03 WO disclosed
WO-2017132617-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI-CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES SUTRO BIOPHARMA, INC. (US) 2017-08-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11572411-B2 Anti-CD117 antibodies and conjugates ITGB7, FUT7, CD2 TOP2A 4847/4885MAP3K5 2953/4885ALDH1A1 197/4885
US-20200255523-A1 FC SILENCED ANTIBODY DRUG CONJUGATES (ADCS) AND USES THEREOF FCGR1A, FCGR2A, FCGR3B TOP2A 4481/4885MAP3K5 4087/4885ALDH1A1 278/4885
US-20220175944-A1 ANTI-CD117 ANTIBODY-DRUG CONJUGATES AND USES THEREOF ITGB7, KIT, CD2 TOP2A 4662/4885MAP3K5 2404/4885ALDH1A1 93/4885
US-20220177577-A1 ANTI-CD117 ANTIBODY DRUG CONJUGATES AND USES THEREOF SIGLEC7, FUT7, ITGB7 TOP2A 4634/4885MAP3K5 2487/4885ALDH1A1 173/4885
US-20200376135-A1 FC SILENCED ANTIBODY DRUG CONJUGATES (ADCS) AND USES THEREOF FCGR1A, FCGR2A, FCGR3B TOP2A 4481/4885MAP3K5 4087/4885ALDH1A1 278/4885
US-20230330248-A1 ANTIBODY-DRUG CONJUGATE INCLUDING NOVEL CYCLIC DINUCLEOTIDE DERIVATIVE STING1, CGAS, TLR9 TOP2A 468/4885MAP3K5 1634/4885ALDH1A1 3436/4885
US-20200207859-A1 METHODS OF USING ANTI-CD74 ANTIBODIES AND ANTIBODY CONJUGATES IN TREATMENT OF T-CELL LYMPHOMA CD74, CD99, CD2 TOP2A 152/4885MAP3K5 4813/4885ALDH1A1 1734/4885
US-20220175946-A1 CONDITIONING METHODS FOR GENE THERAPY CD74, CD2, CD44 TOP2A 2367/4885MAP3K5 4041/4885ALDH1A1 118/4885
US-20200276326-A1 COMPOSITIONS AND METHODS FOR THE DEPLETION OF CD5+ CELLS CD59, CD58, CD47 TOP2A 3700/4885MAP3K5 3690/4885ALDH1A1 651/4885
US-11572370-B2 CD16A binding agents and uses thereof FCGR1A, FCGR2A, FCGR3B TOP2A 3396/4885MAP3K5 1962/4885ALDH1A1 1203/4885
US-20220249683-A1 T-CELL DEPLETING THERAPIES CD2, CD4, CD22 TOP2A 3521/4885MAP3K5 3751/4885ALDH1A1 208/4885
US-20200368363-A1 COMPOSITIONS AND METHODS FOR THE DEPLETION OF CD2+ CELLS CD2, CD22, CD2BP2 TOP2A 3109/4885MAP3K5 3989/4885ALDH1A1 317/4885
US-11583590-B2 Antibody-pyrrolobenzodiazepine derivative conjugate and method of use thereof for treating a tumor EPCAM, PDCD6, CNTN1 TOP2A 933/4885MAP3K5 3634/4885ALDH1A1 3237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.