Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | PYGL | P06737 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011024 | 0.78 | CNR1 (0.50) | GRM7PYGLCNR1MTNR1AMTNR1B | |
| SCHEMBL20182824 | 0.77 | LTB4R (0.56) | MAPTEPHX2GRM7ALDH1A1MEN1 | |
| SCHEMBL12362863 | 0.77 | FUCA1 (0.48) | — | |
| SCHEMBL6198595 | 0.76 | CNR1 (0.48) | GRM7ALDH1A1MEN1KMT2APYGL | |
| SCHEMBL26763722 | 0.75 | CNR1 (0.47) | GRM7PYGLCNR1MTNR1AMTNR1B | |
| SCHEMBL14348199 | 0.75 | PYGL (0.46) | PYGLCNR1MTNR1AMTNR1BMAPK1 | |
| SCHEMBL7910472 | 0.74 | SSTR4 (0.41) | PYGLCNR1MAPK1 | |
| SCHEMBL20678612 | 0.73 | GRM7 (0.62) | GRM7PYGLCNR1 | |
| SCHEMBL20678605 | 0.73 | GRM7 (0.62) | GRM7PYGLCNR1 | |
| SCHEMBL20678754 | 0.73 | GRM7 (0.62) | GRM7PYGLCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017131221-A1 | INDANE DERIVATIVES AS MGLUR7 MODULATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-08-03 | — | — | WO | disclosed |