Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 7/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.37 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24860409 | 0.87 | C3AR1 (0.38) | SIRT5NOD1C3AR1SIRT6SIRT1 | |
| SCHEMBL21322742 | 0.81 | SIRT5 (0.37) | SIRT5C3AR1 | |
| SCHEMBL21322508 | 0.81 | SIRT5 (0.37) | SIRT5C3AR1HPGDSMN1; SMN2CTDSP1 | |
| SCHEMBL19203553 | 0.81 | SIRT5 (0.37) | SIRT5C3AR1 | |
| SCHEMBL20793387 | 0.80 | C3AR1 (0.41) | SIRT5NOD1C3AR1SIRT6SIRT1 | |
| SCHEMBL18051173 | 0.80 | C3AR1 (0.41) | SIRT5NOD1C3AR1SIRT6SIRT1 | |
| SCHEMBL20375713 | 0.80 | C3AR1 (0.41) | SIRT5NOD1C3AR1SIRT6SIRT1 | |
| SCHEMBL21322499 | 0.78 | C3AR1 (0.37) | SIRT5NOD1C3AR1SIRT6SIRT1 | |
| SCHEMBL19170793 | 0.77 | C3AR1 (0.44) | SIRT5NOD1C3AR1SIRT6SIRT1 | |
| SCHEMBL26167079 | 0.77 | C3AR1 (0.38) | SIRT5NOD1C3AR1SIRT6SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017132173-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. (US) | 2017-08-03 | — | — | WO | disclosed |