Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 8/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21322942 | 1.00 | FOLH1 (0.39) | FOLH1OPRL1HPGDHTTSMN1; SMN2 | |
| SCHEMBL19203551 | 0.88 | FOLH1 (0.37) | FOLH1OPRL1SMN1; SMN2ALB | |
| SCHEMBL21322478 | 0.86 | HDAC3 (0.35) | FOLH1OPRL1HDAC3HDAC4HDAC1 | |
| SCHEMBL13113544 | 0.86 | HDAC3 (0.35) | FOLH1OPRL1HDAC3HDAC4HDAC1 | |
| SCHEMBL2734890 | 0.86 | HDAC3 (0.35) | FOLH1OPRL1HDAC3HDAC4HDAC1 | |
| SCHEMBL19203573 | 0.83 | PTGS1 (0.40) | HPGDHTTSMN1; SMN2ALBNOD1 | |
| SCHEMBL24831925 | 0.83 | SIRT2 (0.37) | FOLH1OPRL1HDAC1 | |
| SCHEMBL15626074 | 0.81 | FOLH1 (0.35) | FOLH1OPRL1HPGDHTTSMN1; SMN2 | |
| SCHEMBL278813 | 0.81 | FOLH1 (0.35) | FOLH1OPRL1HPGDHTTSMN1; SMN2 | |
| SCHEMBL19355685 | 0.80 | SMN1; SMN2 (0.41) | FOLH1HPGDHTTSMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3273998-B1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMA (US) | 2019-09-04 | — | — | EP | disclosed |
| WO-2017132173-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. (US) | 2017-08-03 | — | — | WO | disclosed |