Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 8/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21322942 | 0.88 | FOLH1 (0.39) | FOLH1SMN1; SMN2OPRL1ALB | |
| SCHEMBL19203411 | 0.88 | FOLH1 (0.39) | FOLH1SMN1; SMN2OPRL1ALB | |
| SCHEMBL19171172 | 0.87 | SIRT5 (0.38) | SIRT5SMN1; SMN2OPRL1 | |
| SCHEMBL21322508 | 0.83 | SIRT5 (0.37) | SIRT5SMN1; SMN2ALB | |
| SCHEMBL21322478 | 0.80 | HDAC3 (0.35) | FOLH1OPRL1 | |
| SCHEMBL2734890 | 0.80 | HDAC3 (0.35) | FOLH1OPRL1 | |
| SCHEMBL13113544 | 0.80 | HDAC3 (0.35) | FOLH1OPRL1 | |
| SCHEMBL19203408 | 0.76 | SIRT5 (0.41) | SIRT5SMN1; SMN2 | |
| SCHEMBL15626074 | 0.75 | FOLH1 (0.35) | FOLH1SMN1; SMN2OPRL1 | |
| SCHEMBL278813 | 0.75 | FOLH1 (0.35) | FOLH1SMN1; SMN2OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017132173-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. (US) | 2017-08-03 | — | — | WO | disclosed |