Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.52 |
| ▸ | GALR3 | O60755 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL4154776 | 0.98 | LMNA (0.50) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL3952326 | 0.98 | CYP3A4 (0.56) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Methacrylic Acid SCHEMBL8621490 | 0.87 | ACHE (0.45) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL6706932 | 0.86 | MEN1 (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL316506 | 0.85 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1052170 | 0.85 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL31575663 | 0.85 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Methacrylic Acid SCHEMBL2231529 | 0.85 | ACHE (0.43) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL29111296 | 0.84 | LMNA (0.55) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL29809930 | 0.84 | LMNA (0.55) | LMNAMEN1KMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481878-B1 | AMINE COMPOSITION USEFUL FOR MAKING POLYURETHANE FOAM | EVONIK OPERATIONS GMBH (DE) | 2024-05-22 | — | — | EP | claimed |
| US-11605508-B2 | Bio-ionic liquid hydrogels and use of same | ROWAN UNIVERSITY (US) | 2023-03-14 | — | — | US | claimed |
| CN-109476803-B | Amine compositions useful for making polyurethane foams | 赢创运营有限公司 | 2022-04-12 | — | — | CN | claimed |
| US-11021561-B2 | Amine composition useful for making polyurethane foam | EVONIK OPERATIONS GMBH (DE) | 2021-06-01 | — | — | US | claimed |
| US-20210151263-A1 | BIO-IONIC LIQUID HYDROGELS AND USE OF SAME | ROWAN UNIVERSITY | 2021-05-20 | — | — | US | claimed |
| EP-3144332-B1 | NEW TRIMER CATALYST ADDITIVES FOR IMPROVING FOAM PROCESSABILITY | EVONIK OPERATIONS GMBH (DE) | 2020-10-21 | — | — | EP | claimed |
| EP-3481878-A1 | AMINE COMPOSITION USEFUL FOR MAKING POLYURETHANE FOAM | Evonik Degussa GmbH (DE) | 2019-05-15 | — | — | EP | claimed |
| US-20180237686-A1 | METHOD FOR STIMULATION TREATMENT USING POLYMER-SURFACTANT COMBINATION | HALLIBURTON ENERGY SERVICES, INC. (US) | 2018-08-23 | — | — | US | claimed |
| WO-2018013590-A1 | AMINE COMPOSITION USEFUL FOR MAKING POLYURETHANE FOAM | EVONIK DEGUSSA GMBH (DE) | 2018-01-18 | — | — | WO | claimed |
| US-20180009930-A1 | AMINE COMPOSITION USEFUL FOR MAKING POLYURETHANE FOAM | EVONIK OPERATIONS GMBH (DE) | 2018-01-11 | — | — | US | claimed |
| WO-2009055306-A2 | COATING DESIGNS FOR THE TAILORED RELEASE OF DUAL DRUGS FROM POLYMERIC COATINGS | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2009-04-30 | — | — | WO | claimed |
| US-20090104247-A1 | Coating Designs For The Tailored Release Of Dual Drugs From Polymeric Coatings | ABBOTT CARDIOVASCULAR SYSTEMS INC. | 2009-04-23 | — | — | US | claimed |
| WO-2008068467-A1 | METHODS OF TREATING SUBTERRANEAN FORMATIONS USING HYDROPHOBICALLY MODIFIED POLYMERS AND COMPOSITIONS OF THE SAME | HALLIBURTON ENERGY SERVICES, INC. (US) | 2008-06-12 | — | — | WO | claimed |
| US-20080139411-A1 | Methods of treating subterranean formations using hydrophobically modified polymers and compositions of the same | HALLIBURTON ENERGY SERVICES, INC. | 2008-06-12 | — | — | US | claimed |
| US-20070259773-A1 | Trimer catalyst additives for improving foam processability | EVONIK OPERATIONS GMBH (DE) | 2007-11-08 | — | — | US | claimed |
| US-20070259982-A1 | Trimer catalysts with improved processability and surface cure | EVONIK OPERATIONS GMBH (DE) | 2007-11-08 | — | — | US | claimed |
| EP-1852449-A2 | New trimer catalyst with improved processability and surface cure | Air Products and Chemicals, Inc. (US) | 2007-11-07 | — | — | EP | claimed |
| EP-1852450-A2 | New trimer catalyst additives for improving foam processability | Air Products and Chemicals, Inc. (US) | 2007-11-07 | — | — | EP | claimed |
| WO-2004094781-A1 | METHODS OF TREATING SUBTERRANEAN FORMATIONS USING HYDROPHOBICALLY MODIFIED POLYMERS AND COMPOSITIONS OF THE SAME | HALLIBURTON ENERGY SERVICES, INC. (US) | 2004-11-04 | — | — | WO | claimed |
| US-20040209780-A1 | Methods of treating subterranean formations using hydrophobically modified polymers and compositions of the same | HALLIBURTON ENERGY SERVICES, INC. | 2004-10-21 | — | — | US | claimed |