Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | MGAM | O43451 | 3/20 | 0.54 |
| ▸ | SI | P14410 | 3/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.54 |
| ▸ | F2 | P00734 | 2/20 | 0.52 |
| ▸ | F10 | P00742 | 2/20 | 0.52 |
| ▸ | PLG | P00747 | 2/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | PLAT | P00750 | 2/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | F7 | P08709 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179162 | 0.90 | MGAM (0.61) | GUSBGAAMGAMSIMGAM2 | |
| SCHEMBL4496832 | 0.90 | NPC1 (0.57) | GUSBGAAKDM4ENPC1RAB9A | |
| SCHEMBL4496843 | 0.84 | NPC1 (0.68) | GAAF2F10PLGPLAU | |
| SCHEMBL31429762 | 0.84 | GAA (0.66) | GUSBGAAMGAMSIMGAM2 | |
| SCHEMBL31429621 | 0.84 | F7 (0.60) | GUSBGAAMGAMSIMGAM2 | |
| SCHEMBL3136726 | 0.83 | GUSB (0.69) | GUSBGAAMGAMSIMGAM2 | |
| SCHEMBL8564795 | 0.82 | NPC1 (0.50) | GUSBGAAKDM4ENPC1RAB9A | |
| SCHEMBL1170729 | 0.82 | ALDH1A1 (0.57) | KDM4ENPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL14601533 | 0.82 | F7 (0.47) | GUSBGAAMGAMSIMGAM2 | |
| SCHEMBL8108604 | 0.81 | NPC1 (0.69) | GAAKDM4ENPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180004-B1 | CANCER THERAPEUTICS | UNIV VIRGINIA PATENT FOUNDATION (US) | 2021-01-06 | — | — | EP | disclosed |
| US-10562890-B2 | Cancer therapeutics | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2020-02-18 | — | — | US | disclosed |
| US-20170233375-A1 | CANCER THERAPEUTICS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233375-A1 | CANCER THERAPEUTICS | RUNX1, CBFB, MCL1 | GUSB 3562/4885GAA 3552/4885MGAM 4216/4885 |
| US-10562890-B2 | Cancer therapeutics | RUNX1, CBFB, MCL1 | GUSB 3562/4885GAA 3552/4885MGAM 4216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.