Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496843 | 0.94 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL19205885 | 0.90 | GUSB (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8564795 | 0.89 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1170729 | 0.88 | ALDH1A1 (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8108604 | 0.87 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2324292 | 0.86 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL179162 | 0.84 | MGAM (0.61) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2315076 | 0.84 | AURKA (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4813791 | 0.83 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9041717 | 0.82 | STK33 (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482373-B2 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2007-02-01 | — | — | US | disclosed |
| US-7132439-B2 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| US-20040029925-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNA3, KCNB2 | NPC1 1216/4885RAB9A 3054/4885SMN1; SMN2 4422/4885 |
| US-20040029925-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNA3, KCNB2 | NPC1 1216/4885RAB9A 3054/4885SMN1; SMN2 4422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.