Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 3/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9895811 | 0.73 | LIPE (0.41) | HPGDLIPEGABRA5MAPK1HCRTR1 | |
| SCHEMBL19256719 | 0.73 | HCRTR1 (0.44) | HPGDLIPEGABRA5KMT2AMAPK1 | |
| SCHEMBL29560752 | 0.73 | HCRTR1 (0.44) | HPGDLIPEGABRA5KMT2AMAPK1 | |
| SCHEMBL19207168 | 0.73 | HCRTR1 (0.44) | HPGDLIPEGABRA5KMT2AMAPK1 | |
| SCHEMBL19256718 | 0.73 | HCRTR1 (0.44) | HPGDLIPEGABRA5KMT2AMAPK1 | |
| Hydrochloric Acid SCHEMBL29912861 | 0.69 | GABRA5 (0.41) | HPGDLIPEGABRA5KMT2AMAPK1 | |
| Hydrochloric Acid SCHEMBL27158684 | 0.69 | GABRA5 (0.41) | HPGDLIPEGABRA5KMT2AMAPK1 | |
| Hydrochloric Acid SCHEMBL27158683 | 0.69 | GABRA5 (0.41) | HPGDLIPEGABRA5KMT2AMAPK1 | |
| SCHEMBL10121582 | 0.69 | HPGD (0.38) | HPGDLIPEGABRA5KMT2AMAPK1 | |
| SCHEMBL22761804 | 0.69 | LTA4H (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414241-A1 | HALO-SUBSTITUTED PIPERIDINES AS OREXIN RECEPTOR MODULATORS | Astrazeneca AB (SE) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139603-A1 | HALO-SUBSTITUTED PIPERIDINES AS OREXIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2017-08-17 | — | — | WO | disclosed |