Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | VIPR2 | P41587 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207280 | 0.90 | CNR2 (0.40) | CNR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19207259 | 0.88 | RAB9A (0.45) | NPC1RAB9AKMT2AMEN1RXFP1 | |
| SCHEMBL19207317 | 0.85 | NR3C2 (0.39) | NPC1RAB9AKMT2AMEN1ADORA3 | |
| SCHEMBL19207292 | 0.83 | CNR2 (0.40) | CNR2SMN1; SMN2HTT | |
| SCHEMBL19207297 | 0.83 | WDR5 (0.41) | — | |
| SCHEMBL19207274 | 0.83 | KMO (0.38) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19207306 | 0.82 | NR3C2 (0.37) | MAPTTP53PDE4DALDH1A1 | |
| SCHEMBL19207322 | 0.81 | LMNA (0.39) | NPC1RAB9AADORA3MAPTTP53 | |
| SCHEMBL19207334 | 0.81 | CNR1 (0.43) | ADORA3 | |
| SCHEMBL19641897 | 0.80 | PDE4A (0.39) | CNR2PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411365-A1 | PYRAZOL-PYRIDINE DERIVATIVES AS EAAT3 INHIBITORS | H. Hoffnabb-La Roche Ag (CH) | 2018-12-12 | — | — | EP | claimed |
| WO-2017133990-A1 | PYRAZOL-PYRIDINE DERIVATIVES AS EAAT3 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-10 | — | — | WO | claimed |