Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 6/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8903935 | 0.85 | SMN1; SMN2 (0.40) | MEN1KMT2ASMN1; SMN2LMNAGAA | |
| SCHEMBL22494002 | 0.82 | MTNR1A (0.41) | MEN1KMT2ASMN1; SMN2LMNAGAA | |
| SCHEMBL19224503 | 0.82 | NFKB1 (0.51) | KMT2AL3MBTL1CCKBR | |
| SCHEMBL19207684 | 0.82 | NFKB1 (0.51) | KMT2AL3MBTL1CCKBR | |
| SCHEMBL9041574 | 0.80 | CCKBR (0.54) | CCKBR | |
| SCHEMBL3601522 | 0.72 | MEN1 (0.36) | MEN1KMT2ALMNAMAPT | |
| SCHEMBL28702219 | 0.70 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2LMNAGAA | |
| SCHEMBL15956793 | 0.67 | RIPK1 (0.57) | EGFRCCKBRRIPK1 | |
| SCHEMBL4276864 | 0.66 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2LMNAP2RX4 | |
| Iodide SCHEMBL28443511 | 0.65 | MEN1 (0.48) | MEN1KMT2ASMN1; SMN2LMNAP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |